The 2012 Mercedes-Benz R350 is available in multiple trims, each with its own estimated fuel economy, here are the EPA estimates for each trim:

1. : 16 MPG City and 21 MPG Highway
2. CDI: 18 MPG City and 23 MPG Highway

It is important to remember factors such as driving style, weather conditions, and the use of features such as Eco mode can impact fuel efficiency.

The Mercedes-Benz R350 received a rating of 3 out of 5 stars from RepairPal, which RepairPal describes as Average. This rating ranks the Mercedes-Benz R350 as 8​​ out of 20​​ among Luxury Fullsize SUV

The 2012 Mercedes-Benz R350 has a maximum towing capacity of 3500 pounds, when properly equipped. Various factors may impact towing capacity, including weight of passengers, cargo, and options/accessories.

Here is what's new for the 2012 Mercedes-Benz R350:

• Front Seat Heaters
• Power Folding Third Row
• Skylight(s)
• Rear Air Conditioning
• Power Hatch/Deck Lid