The 2021 Toyota Avalon Hybrid is available in multiple trims, each with its own estimated fuel economy, here are the EPA estimates for each trim:

1. XLE: 43 MPG City and 44 MPG Highway
2. XSE: 43 MPG City and 43 MPG Highway
3. Limited: 43 MPG City and 43 MPG Highway

It is important to remember factors such as driving style, weather conditions, and the use of features such as Eco mode can impact fuel efficiency.