The 2022 Toyota Prius Prime Hybrid is available in multiple trims, each with its own estimated fuel economy, here are the EPA estimates for each trim:

1. XLE: 145 MPG City and 121 MPG Highway + battery range of 25 miles
2. LE: 145 MPG City and 121 MPG Highway + battery range of 25 miles
3. Limited: 145 MPG City and 121 MPG Highway + battery range of 25 miles

It is important to remember factors such as driving style, weather conditions, and the use of features such as Eco mode can impact fuel efficiency.