The 2021 Audi S5 is available in multiple trims, each with its own estimated fuel economy, here are the EPA estimates for each trim:

1. Prestige : 20 MPG City and 27 MPG Highway
2. Premium : 20 MPG City and 27 MPG Highway
3. Premium Plus : 20 MPG City and 27 MPG Highway

It is important to remember factors such as driving style, weather conditions, and the use of features such as Eco mode can impact fuel efficiency.

The Audi S5 received a rating of 2 out of 5 stars from RepairPal, which RepairPal describes as Average. This rating ranks the Audi S5 as 62​​ out of 68​​ among Luxury Midsize Car

Here is what's new for the 2021 Audi S5:

• A/C Seat(s)
• Heated Steering Wheel
• Panoramic Sunroof
• Seat Massagers
• Lane Departure Warning