The 2021 Lexus ES 250 is available in multiple trims, each with its own estimated fuel economy, here are the EPA estimates for each trim:

1. Base: 25 MPG City and 34 MPG Highway
2. Luxury: 25 MPG City and 34 MPG Highway
3. Ultra Luxury: 25 MPG City and 34 MPG Highway
4. F-Sport: 25 MPG City and 34 MPG Highway

It is important to remember factors such as driving style, weather conditions, and the use of features such as Eco mode can impact fuel efficiency.

The 2021 Lexus ES 250 has a maximum towing capacity of 1000 pounds, when properly equipped. Various factors may impact towing capacity, including weight of passengers, cargo, and options/accessories.