The 2022 Lexus ES 250 is available in multiple trims, each with its own estimated fuel economy, here are the EPA estimates for each trim:

1. Base : 25 MPG City and 34 MPG Highway
2. Luxury : 25 MPG City and 34 MPG Highway
3. Ultra Luxury : 25 MPG City and 34 MPG Highway
4. F-Sport : 25 MPG City and 34 MPG Highway

It is important to remember factors such as driving style, weather conditions, and the use of features such as Eco mode can impact fuel efficiency.

Here is what's new for the 2022 Lexus ES 250:

• Blind Spot Monitor
• Android Auto
• Apple CarPlay
• Navigation System
• Pioneer Sound System