The 2022 Lexus NX 350 is available in multiple trims, each with its own estimated fuel economy, here are the EPA estimates for each trim:

1. Base: 22 MPG City and 29 MPG Highway
2. Premium: 22 MPG City and 29 MPG Highway
3. Luxury: 22 MPG City and 29 MPG Highway
4. F-SPORT Handling: 22 MPG City and 28 MPG Highway

It is important to remember factors such as driving style, weather conditions, and the use of features such as Eco mode can impact fuel efficiency.

The 2022 Lexus NX 350 has a maximum towing capacity of 2000 pounds, when properly equipped. Various factors may impact towing capacity, including weight of passengers, cargo, and options/accessories.