2022 Mercedes-Benz E350 review
Mercedes-Benz E350 highlights
Customer rating
Mileage (EPA estimate)
22 city, 31 highway, 25 combined
Pricing for current inventory
(no current inventory)
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All Mercedes-Benz E350 years
What is new for the 2022 Mercedes-Benz E350?
- Enhanced safety features now included as standard across all models.
- New infotainment system with improved responsiveness and additional app compatibility.
- Increased fuel efficiency ratings due to engine optimizations.
- Optional all-wheel drive is now available on lower trim levels.
- Standard warranty coverage extended to 5 years or 60,000 miles.
2022 Mercedes-Benz E350 trims
Curious how Mercedes-Benz E350 trims differ? Use our side-by-side vehicle comparison to see the differences and similaritiesBase:
- 255-hp, 273-lb-ft of torque 2.0L
- Side Airbags
- Overhead Airbags
- Sunroofs
- Rear Defroster
- Cruise Control
- Power Seats
- Memory Seats
- Front Seat Heaters
- View our Mercedes-Benz E350 inventory
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Ratings & reliability
RepairPal gave the Mercedes-Benz E350 an overall reliability rating of 3.5 out of 5 stars, which RepairPal describes as Above Average. This rating ranks Mercedes-Benz E350 10th out of 48 among Luxury Fullsize Cars.
View RepairPal's full rating of the Mercedes-Benz E3502022 Mercedes-Benz E350 FAQ
The 2022 Mercedes-Benz E350 has received an average 5.0 out of 5 stars from our customers. If you're in the market for a 2022 Mercedes-Benz E350, check out reviews from customers just like you. 2022 Mercedes-Benz E350 Reviews.
The Mercedes-Benz E350 received a rating of 3.5 out of 5 stars from RepairPal, which RepairPal describes as Above Average. This rating ranks the Mercedes-Benz E350 as 10 out of 48 among Luxury Fullsize Car
Here is what's new for the 2022 Mercedes-Benz E350:
- Automated Parking
The 2022 Mercedes-Benz E350 offers the following fuel efficiency options: • Gas: 22 city / 31 highway MPG Actual mileage may vary based on driving conditions, vehicle condition, and driving habits.
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We hope you found this information helpful. This content is intended to inform and is not meant to indicate that a particular vehicle is currently available or recommended for you.
Statements of fuel economy or EV range are based on EPA and other third-party estimates for vehicles when new. Fuel economy and EV range will degrade with time and vary based on age, driving conditions, vehicle history, and other conditions. See fueleconomy.gov for more info.
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We make every effort to provide accurate information, but please verify before purchasing.

