beebs

2021 Mercedes-Benz E350 review

Research, photos, specs, and expertise

Mercedes-Benz E350 highlights

Customer rating

RepairPal reliability rating

RepairPal Reliability Ratings are based on the actual cost, frequency, and severity of unscheduled repairs and maintenance on make/model data for select 2008-2022 vehicles. The reliability of a specific vehicle may vary depending on its maintenance and driving history, model year, trim, and features. RepairPal Reliability Ratings are provided by RepairPal and CarMax is not responsible for their accuracy. These ratings are based on RepairPal Reliability data as of August 2023. Learn more about RepairPal reliability ratings

Mileage (EPA estimate)

22 city, 30 highway, 25 combined

Pricing for current inventory

(no current inventory)

View our Mercedes-Benz E350 inventory
Lighting bolt logo
Can an EV fit my lifestyle? Image of woman on smartphone while charging an EV

Does an EV fit my lifestyle?

On this page

Find your E350
then buy online or in-store

Learn more about getting pre-qualified with no impact to your credit score
Price
Year
Search our E350 inventorySearch for a different car

All Mercedes-Benz E350 years

What is new for the 2021 Mercedes-Benz E350?

  • E350 trims have been upgraded with Front Seat Heaters and Run Flat Tires as standard equipment this year.
  • Rear Seat Heaters features are now available as options on select trims.

2021 Mercedes-Benz E350 trims

Curious how Mercedes-Benz E350 trims differ? Use our side-by-side vehicle comparison to see the differences and similarities

Base:

Shop with your budget in mind

Getting pre-qualified lets you shop with personalized monthly payments, and it doesn't impact your credit score.Get Pre-qualified

Ratings & reliability

Customer ratings

5 out of 5

1 customer reviews

RepairPal reliability rating

RepairPal Reliability Ratings are based on the actual cost, frequency, and severity of unscheduled repairs and maintenance on make/model data for select 2008-2022 vehicles. The reliability of a specific vehicle may vary depending on its maintenance and driving history, model year, trim, and features. RepairPal Reliability Ratings are provided by RepairPal and CarMax is not responsible for their accuracy. These ratings are based on RepairPal Reliability data as of August 2023. Learn more about RepairPal reliability ratings

3
1
2
Above Average

RepairPal gave the Mercedes-Benz E350 an overall reliability rating of 3.5 out of 5 stars, which RepairPal describes as Above Average. This rating ranks Mercedes-Benz E350 10th out of 48 among Luxury Fullsize Cars.

View RepairPal's full rating of the Mercedes-Benz E350

2021 Mercedes-Benz E350 FAQ

Mercedes-Benz E350 articles

Best Diesel Cars: Abstract | CarMax

Best Used Diesel Cars

If you're looking for a fuel-sipping car, why not pick one with a diesel powertrain? Find out more about the benefits—and choose one that suits your lifestyle—with this list of the best used diesel cars, based on CarMax sales data from January 10, 2020 through March 31, 2021.

Want to view more trending articles?

Research other vehicles


* Price excludes taxes, title, registration, and fees. Applicable transfer fees are due in advance of vehicle delivery and are separate from sales transactions.

We hope you found this information helpful. This content is intended to inform and is not meant to indicate that a particular vehicle is currently available or recommended for you.​

Statements of fuel economy or EV range are based on EPA and other third-party estimates for vehicles when new. Fuel economy and EV range will degrade with time and vary based on age, driving conditions, vehicle history, and other conditions. See fueleconomy.gov for more info.

Unless otherwise noted, information related to featured vehicles comes from third-party sources, including manufacturer information. Product and company names may be trademarks or registered trademarks of third-party entities. Use of them does not imply any affiliation with or endorsement by these entities.​ By clicking on any video links, you will be taken to a third-party site maintained by YouTube, Inc.

We make every effort to provide accurate information, but please verify before purchasing.