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2021 Mercedes-Benz E350 review

Research, photos, specs, and expertise

Mercedes-Benz E350 highlights

Customer rating

RepairPal reliability rating

RepairPal Reliability Ratings are based on the actual cost, frequency, and severity of unscheduled repairs and maintenance on make/model data for select 2008-2022 vehicles. The reliability of a specific vehicle may vary depending on its maintenance and driving history, model year, trim, and features. RepairPal Reliability Ratings are provided by RepairPal and CarMax is not responsible for their accuracy. These ratings are based on RepairPal Reliability data as of August 2023. Learn more about RepairPal reliability ratings

Mileage (EPA estimate)

22 city, 30 highway, 25 combined

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All Mercedes-Benz E350 years

What is new for the 2021 Mercedes-Benz E350?

  • E350 trims have been upgraded with Front Seat Heaters and Run Flat Tires as standard equipment this year.
  • Rear Seat Heaters features are now available as options on select trims.

2021 Mercedes-Benz E350 trims

Curious how Mercedes-Benz E350 trims differ? Use our side-by-side vehicle comparison to see the differences and similarities

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Ratings & reliability

Customer ratings

5 out of 5

1 customer reviews

RepairPal reliability rating

RepairPal Reliability Ratings are based on the actual cost, frequency, and severity of unscheduled repairs and maintenance on make/model data for select 2008-2022 vehicles. The reliability of a specific vehicle may vary depending on its maintenance and driving history, model year, trim, and features. RepairPal Reliability Ratings are provided by RepairPal and CarMax is not responsible for their accuracy. These ratings are based on RepairPal Reliability data as of August 2023. Learn more about RepairPal reliability ratings

3
1
2
Above Average

RepairPal gave the Mercedes-Benz E350 an overall reliability rating of 3.5 out of 5 stars, which RepairPal describes as Above Average. This rating ranks Mercedes-Benz E350 10th out of 48 among Luxury Fullsize Cars.

View RepairPal's full rating of the Mercedes-Benz E350

2021 Mercedes-Benz E350 FAQ

Mercedes-Benz E350 articles

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Statements of fuel economy or EV range are based on EPA and other third-party estimates for vehicles when new. Fuel economy and EV range will degrade with time and vary based on age, driving conditions, vehicle history, and other conditions. See fueleconomy.gov for more info.

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